General Information

  • ID:  hor005026
  • Uniprot ID:  P84211
  • Protein name:  Bombesin-like peptide 2
  • Gene name:  NA
  • Organism:  Bombina variegata (Yellow-bellied toad)
  • Family:  Bombesin/neuromedin-B/ranatensin family
  • Source:  animal
  • Expression:  Expressed by the skin glands.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Bombina (genus), Bombinatoridae (family), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity
  • GO BP:  GO:0006952 defense response; GO:0007218 neuropeptide signaling pathway; GO:0050796 regulation of insulin secretion
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QSFGNQWARGHFM
  • Length:  13
  • Propeptide:  QSFGNQWARGHFM
  • Signal peptide:  NA
  • Modification:  T1 Pyrrolidone carboxylic acid;T13 Methionine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Possesses insulin-releasing activity.
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor005026_AF2.pdbhor005026_ESM.pdb

Physical Information

Mass: 177995 Formula: C70H96N22O18S
Absent amino acids: CDEIKLPTVY Common amino acids: FGQ
pI: 10.55 Basic residues: 2
Polar residues: 4 Hydrophobic residues: 4
Hydrophobicity: -87.69 Boman Index: -2637
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 7.69
Instability Index: 463.08 Extinction Coefficient cystines: 5500
Absorbance 280nm: 458.33

Literature

  • PubMed ID:  15134346
  • Title:  Skin secretion of the toad Bombina variegata contains multiple insulin-releasing peptides including bombesin and entirely novel insulinotropic structures.